{"id":1631,"date":"2013-07-16T10:11:34","date_gmt":"2013-07-16T10:11:34","guid":{"rendered":"https:\/\/dev.bulevar360.com\/?p=1631"},"modified":"2013-07-16T10:11:34","modified_gmt":"2013-07-16T10:11:34","slug":"glaucoma-y-cannabis","status":"publish","type":"post","link":"https:\/\/agrobeta.com\/agrobetablog\/2013\/07\/glaucoma-y-cannabis\/","title":{"rendered":"Glaucoma y cannabis"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img fetchpriority=\"high\" decoding=\"async\" class=\" wp-image-1632 aligncenter\" src=\"https:\/\/dev.bulevar360.com\/wp-content\/uploads\/2013\/07\/glaucoma.jpg\" alt=\"glaucoma\" width=\"567\" height=\"460\" data-id=\"1632\" srcset=\"https:\/\/agrobeta.com\/agrobetablog\/wp-content\/uploads\/2013\/07\/glaucoma.jpg 567w, https:\/\/agrobeta.com\/agrobetablog\/wp-content\/uploads\/2013\/07\/glaucoma-300x243.jpg 300w\" sizes=\"(max-width: 567px) 100vw, 567px\" \/><\/p>\n<p>El glaucoma es una enfermedad de los ojos que se caracteriza generalmente por el aumento patol\u00f3gico de la presi\u00f3n intraocular por falta de drenaje del humor acuoso aunque no es la regla, y tiene como condici\u00f3n final com\u00fan una neuropat\u00eda \u00f3ptica que se caracteriza por la p\u00e9rdida progresiva de las fibras nerviosas del nervio \u00f3ptico y cambios en su aspecto.<\/p>\n<p><!--more--><\/p>\n<p>En las primeras fases de la enfermedad, la mayor\u00eda de las personas afectadas no presentan s\u00edntomas; m\u00e1s adelante aparecen defectos en el campo visual y p\u00e9rdida progresiva de visi\u00f3n.<\/p>\n<p>Los cannabinoides adem\u00e1s de disminuir la presi\u00f3n intraocular inhibir\u00edan la apoptosis y actuar\u00edan como neuroprotectores.<\/p>\n<p>En los a\u00f1os 70 en un estudio estadounidense con sujetos fumadores de marihuana descubrieron su potente efecto reductor de la presi\u00f3n intraocular. Posteriormente se corrobor\u00f3 esta observaci\u00f3n con otros experimentos administrando el principal componente activo de la marihuana el delta-9-tetrahidrocannabinol, v\u00eda oral y endovenosa. Aunque los efectos psicoactivos limitaban su uso terap\u00e9utico se investigaron los mecanismos de acci\u00f3n, se potenci\u00f3 el estudio de los cannabinoides sint\u00e9ticos y se descubri\u00f3 un sistema end\u00f3geno de cannabinoides, an\u00e1logos de las prostaglandinas con una vida media corta, con funciones neuromoduladoras, neuroprotectoras y reguladoras de la presi\u00f3n intraocular.<\/p>\n<p><img decoding=\"async\" class=\"alignright size-full wp-image-1633\" src=\"https:\/\/dev.bulevar360.com\/wp-content\/uploads\/2013\/07\/images-5.jpg\" alt=\"images (5)\" width=\"244\" height=\"183\" data-id=\"1633\" \/><\/p>\n<p>Los cannabinoides ofrecen una opci\u00f3n terap\u00e9utica muy completa y complementaria al actual arsenal antiglaucomatoso ya que adem\u00e1s de disminuir la presi\u00f3n intraocular inhibir\u00edan la apoptosis y actuar\u00edan como neuroprotectores. Pero la dificultad para el uso terap\u00e9utico t\u00f3pico de estas sustancias se debe principalmente a su efecto psic\u00f3tropo; en la administraci\u00f3n t\u00f3pica pr\u00e1cticamente el 90% se absorbe por la mucosa nasal y conjuntival y sus efectos sobre el receptor CB1. Son sist\u00e9micos. Adem\u00e1s, son mol\u00e9culas altamente lipof\u00edlicas y muy poco solubles en la l\u00e1grima. Actualmente se est\u00e1n realizando estudios con la anandamida (principal representante de los endocannabinoides) y ciclodextrinas que aumentan su solubilidad y disminuyen la dosis de aplicaci\u00f3n necesaria.<\/p>\n<p>Tambi\u00e9n se est\u00e1 potenciando el estudio de cannabinoides sint\u00e9ticos sin efectos psic\u00f3tropos como el HU211 como potentes efectos antioxidantes.<\/p>\n<p>Bibliograf\u00eda:<\/p>\n<p>&#8211; http:\/\/es.wikipedia.org\/wiki\/Glaucoma<\/p>\n<p>&#8211; Doctora Marta Castany. Oftalm\u00f3loga. \u00a02004-2009.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; El glaucoma es una enfermedad de los ojos que se caracteriza generalmente por el aumento patol\u00f3gico de la presi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1632,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[13,14],"tags":[983,472,615,1161,1162,1163,1164,1165,476,1166,622,153],"class_list":["post-1631","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cannabis","category-cannabis-medicinal","tag-cannabinoides","tag-cannabis-medicinal-2","tag-cbd","tag-glaucoma-ocular","tag-glaucoma-ocular-y-cannabis","tag-glaucoma-ocular-y-marihuana","tag-glaucoma-y-cannabis","tag-glaucoma-y-marihuana","tag-marihuana-medicinal","tag-neuropatologias","tag-tetrahidrocannabinol","tag-thc"],"_links":{"self":[{"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/posts\/1631","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/comments?post=1631"}],"version-history":[{"count":0,"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/posts\/1631\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/media\/1632"}],"wp:attachment":[{"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/media?parent=1631"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/categories?post=1631"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agrobeta.com\/agrobetablog\/wp-json\/wp\/v2\/tags?post=1631"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}